Manufactured Levothyroxine can be efficiently used to treat hyperthyroidism & related symptoms

Learn about Levothyroxine impurity and related information. Levothyroxine, or L-thyroxine, is an artificial form of the thyroxine hormone that is used to cure related ailments. The thyroid hormones, triiodothyronine (T3) and thyroxin (T4) are primarily responsible for regulation of metabolism. Tyrosine-based these two hormones are produced by the thyroid gland. Both T3 and T4 are used to treat thyroid hormone deficiency known as hypothyroidism, including the severe form known as myxedema coma. The pharmaceutical name of Levothyroxine sodium (T4) is Levothyroxine more pure, synthetic form of Thyroid.

INDICATIONS:

Introduced in the 1950s Levothyroxine is typically used in the cure for people with hypothyroidism that regularly requires lifelong thyroid hormone remedy. Levothyroxine is also used to treat subclinical hypothyroidism which is defined by araised TSH level and is milder than usual. Such people may be asymptomatic and can’t be predicted whether they should be treated or they don’t require any sort of treatment.

CONTRAINDICATIONS:

Levothyroxine is contraindicated in the following:

• Levothyroxine degrades rapidly with exposure to light, moisture, and oxygen.
• thyroid disorder called thyrotoxicosis
• sort of heart, coronary artery disease, or any history of blood clots
• diabetes (insulin or oral medication dosages must be changed when you start Levothyroxine medicine)
• anemia
• low bone mineral density or osteoporosis
• any problems with your pituitary gland
• food or drug allergy
• untreated adrenal gland disorder
• Not suggested in people who have had a recent heart attack.

During the manufacturing process or storage of the drug elements, impurities present in the form of by-products or so called process impurities are possible.

All impurities of Levothyroxine obtained are given below.

1. Levothyroxine T4-Amine O-methyl Impurity / O-Methyl-Tetraiodothyroethylamine
2. Levothyroxine acetamide Impurities (T4-Acetamide)
3. Levothyroxine EP Impurities A, Levothyroxine
4. Levothyroxine EP Impurities C, T3-Acetic Acid (USP)
5. Levothyroxine EP Impurities D, T4-Acetic Acid (USP)
6. Levothyroxine EP Impurities F, Levothyroxine T6 Impurity (USP)
7. Levothyroxine EP Impurities H, T4-Benzoic Acid (USP)
8. Levothyroxine EP Impurities I, T4-Aldehyde (USP)
9. Levothyroxine EP Impurity J, 3,3’-Diiodo-L-Thyronine
10. Levothyroxine EP Impurity K, 3,3’,5’-Triiodo-L-Thyronine
11. Levothyroxine N-Acetyl Impurities, 1 N-Acetyl-T4 (USP)
12. Levothyroxine N-Formyl Impurity,N-Formyl-T4 (USP)
13. Levothyroxine N-Methylamide (USP)
14. Levothyroxine O-Methyl impurity
15. Levothyroxine T4-Hydroxy Acetic Acid Impurities
16. Levothyroxine T4-Thyrolactic acid Impurities

SIDE EFFECTS:

Excessive dosages include weight loss, disability in tolerating heat, sweating, anxiety, sleeping problems, shivering, and rise in heartbeat rate. Consult your doctor if you had a recent heart attack, or experience any symptoms of a heart attack such as chest pain or heavy feeling in heart, pain spreading to the shoulder, nausea, sweating or general ill feeling). Consuming this during pregnancy has been found to be safe if recommendation of dosing is based on regular check-ups of TSH and T4 levels in the blood. One benefit of treating this people with Levothyroxine therapy is preventing enhancement of hypothyroidism.

Manufactured Levothyroxine can be efficiently used to treat hyperthyroidism and related symptoms. The process of synthesizing artificial Levothyroxine is well documented and the Levothyroxine impurities are stringent. These are based on the guidelines of the ICH & pharmacopeia.

Implications of Solifenacin Impurity in Drugs

The medicinal impurity Solifenacin Impurity is used in medicines prepared to treat bladder problems. The drug Solifenacin is used to cure overactive urinary bladders. Usually people facing problems such as frequent urination, or an immediate urgency to urinate, or leakage of urine, are treated with doses of Solifenacin. It is basically considered as a muscarinic receptor antagonist.

The working of Solifenacin is accomplished by blocking or retarding the action of specific chemical substances in our body. This in turn helps the patients in reduction of urination complications that are caused by overactive bladder. But, it is recommended not to take the drug if the patient is allergic to any of its ingredients.It should be noted that the Solifenacin drug is being effective in reducing the complications of an overactive bladder.

The complication of an overactive bladder is a widespread across the globe. And, this results in having an adverse effect on a person’s identity and the quality of life. The issue of frequent or uncontrolled urination does impact the overall physiological phenomenon in human body. The basic medication for treating an overactive bladder and or the urgency incontinence is given as in small doses of antimuscarinic drug such as Solifenacin and along with a combination of behavioural therapy.

It is informative to know that Solifenacin succinate was introduced in the year 2005. And, it has successfully proved itself in the short and long term clinical trials as well. Solifenacin is known as a M3 receptor antagonist that has a half-life period of about 45 to 68 hours. The effectiveness of the drug solifenacinin curing the diseases related to overactive bladder has been proved in several clinical trials.

How the drug Solifenacin works?

The treatment of overactive bladder by having Solifenacin doses is known to all now.The main thing to understand here is that an overactive bladder and a normal one function distinctly.The phenomenon of a normal bladder to swell like a balloon when it gets filled with urine is quiet natural. This is what we world call a regular event. It then sends signals to the brain that it should be emptied. And, when you go to urinate, the urinary bladder contracts to expel the urine out.

While in case of an overactive bladder, the muscle of the urinary bladder begins contractions before the bladder is filled to its maximum volume. This makes the muscle work over time. This is why a person suffering with the complication faces the sudden urges to urinate.

Here comes the role to be played by the drug Solefenacin. It helps the muscle of the urinary bladder to contract according to the need. It does so by binding the muscle with some receptors or natural body proteins. And, as a result the urge to urinate decreases.

The impurities associated with Solefenacin:

The drug Solifenacin comes associated with impurities such as Solifenacin impurity A, B, and C, RR Solifenacin, Solifenacin SS Methanone Impurity, Solifenacin succinate, RS Solifenacin, SS Solifenacin, Solifenacin RS Methanone Impurity, and Solifenacin Isomer.