Tuesday, 30 August 2016

Acyclovir Impurity Standards and its Importance

Acyclovir is a drug used for treating viral diseases or infections. The major viral diseases which can be cured by Acyclovir are Herpes Simplex Virus infections, Chicken Pox, Shingles, and Cold Sores. The medicine is available in oral form as well as can be taken by injection. There are few side effects for this drug, which include nausea, vomiting, headache, mouth pain and diarrhea. It is found to be safe during pregnancy, however people who have kidney diseases are requested to take great care and consult with doctor. If people found any bleeding, red spots in skin and face, symptoms of kidney problem they must immediately consult with doctor. Patients administered with this drug are advised to drink a lot of water to ensure the proper functioning of kidney.

You can understand the importance of this drug from the above description. Also see the side effects that might occur in few patients. It shows that the medicine intake should be with proper care and after proper consultation with doctor. It is important that patients are taking good quality medicines. Considering there are many pharmaceutical companies manufacturing this drug, how do we ensure that it is of good quality? We can ensure it by looking at the government certification on drug packet. The medicines would have certification of Central Drugs Standard Control Organization (CDSCO) in India to ensure the quality.

But did you look at how the pharmaceutical companies are ensuring the quality after preparing the drug. We can look at that and look at a list of Acyclovir Impurity Standards

How to Ensure Quality?
Quality can be ensured by a two-step process after preparing the medicine. First is by removing unwanted particles from the drug prepared. Then proceed to testing to see whether it brings the desired result. The first process needs much explanation and the second one is testing and it has to be done in the procedural way. Since the removal of unwanted particles required further clarification, let us look what is it? As we all know that the drugs are prepared from chemical compounds and it needs a lot a chemical reaction to make the final product. Many of the raw chemical won’t be in pure condition. Also during chemical processes other impurities might get added to drug and may change the chemical combination slightly. If it is not removed, it would affect the effectiveness of the medicine. That removal is executed by using Impurity Standards. These are set of procedures which uses chemicals and chemical reactions to remove the impurities in it.

In case of Acyclovir Impurity Standards, there are many sub-categories of impurity standards are available from the manufacturers. Some of them are Acyclovir Di- Acetyl Gaunin Impurity, Acyclovir Hydroxy Methyl Impurity, Acyclovir Impurity A, Acyclovir Impurity B, Acyclovir Impurity C, Acyclovir Impurity D, Acyclovir Impurity F, Acyclovir Impurity K, Acyclovir Impurity P etc.


Though you can find many types of Acyclovir Impurity Standards, a pharmaceutical company would choose the appropriate one considering the raw materials or chemical compounds they used. Usually they check with the manual of the Impurity standards which are available in manufacturer’s website to ensure they are taking the right pick. 

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