Can Losartan Make a Comeback?

Losartan is a drug which acts as an angiotensin II antagonist and is thus used to treat patients with high blood pressure levels. However, losartan is not found in the market by this name but, it is rather found in the market by a completely different name known as Cozaar. This drug is marketed by the Merek and Co. Inc. it is available in the market in generic form.

Uses of losartan

Losartan is used to treat hyper pressure since it has got angiotensin. This drug is also used in treating the cases of nephropathy and renal diseases. Though it cannot cure the renal disease but, it can slow down the advent of disease and thus helps the patient to buy some time to get the proper medical diagnosis and also to get the appropriate treatment from doctors. Although the calcium channel blockers are always considered to be the first hand treatment that the patient needs but, an angiotensin II antagonist is also preferred for the patients who are under the age of 55 and are not able to tolerate the ACE test and its necessary treatments. Scientific study has already proven the fact that losartan is much better than atenolol when it comes to the treatment of cardiovascular problems. Losartan reduces the cardiovascular morbidity and mortality and thereby it helps in the reduction of blood pressure in the most effective and smooth manner. The time of action of this drug is also very fast and short and thus it can be certainly used during the time of an emergency.

Mechanism of action

Losartan is such a type of drug that due to its angiotensin II antagonism it reduces the peripheral resistance which is also known as the after load and the cardiac venous return which is also known as the preload. In this way this drug reduced the pressure that the blood exerts on the walls of the blood vessels and arteries and thus saves the patient from having a heart attack or stroke.  Losartan can even act a uricosuric. This drug helps in the blockage of the chemical uric from entering our blood and thus with the help of the kidney, the necessary amount of uric and its related compounds are excreted from our body in an effective manner.

Disadvantages of using Losartan

But as of 2014, the FDA had announced that losartan has got a fatal effect over the human body is used for a prolonged time and hence forth should not found in any kind of medicine shop or market. Its production had also been stopped. The most common side effects of this drug are dizziness, respiratory infections and immense amount of back pain. That’s why the scientists all over the world are now trying to find the best possible way in which they can synthesise the various impurities of losartan and thus, can also remove them. Hopefully, then it will be brought to the market again and then can be used by the patients without having any side effects and ill effects.

When is the Best Time to take Allergy Medicine?

The reaction of body’s immune system to the harmless substances is known as allergy. Nausea, asthma and hives are some of the common causes of allergies. The mild allergies can be controlled using symptomatic treatments.

Anti – histamines are able to help and provide relief to a person suffering from allergies. Although each and every medication should be taken on time, however the allergy medication should be taken before bedtime. It is important to take the medication at a time when it gets properly absorbed in the bloodstream and is able to get highest level of exposure. When you take the allergy medication before sleeping, the medication will circulate completely in the body through the blood stream.

Hay fever becomes worse during the night time and becomes really severe once the patient gets up in the morning. It is because during the morning time the level of histamines which trigger the system are highest. This explains why taking medicine before dinnertime can be helpful for people suffering from allergies. Also, since the anti-histamines are able to reach peak after 8 – 12 hours, dinner time medication is the most preferred option.

How to decide the right time to take allergy medicine?

It is important to understand the right time when the medication needs to be administered. This is important because administering the medication at the right time will help in its proper absorption in the blood stream which will help the patient heal quickly and get rid of any kind of allergy symptoms.

There are few factors that need to be taken into consideration while selecting the right time for medication.

1. Regularity: Regularity explains the number of days a medicine is taken. The allergy medicine should be taken regularly i.e. once or twice daily as prescribed by the doctor.

2. Absorption in the blood stream: The medication needs to be taken at a time when the medicine is properly absorbed by the body. These can be during two times of the day, once before sleeping when the medication gets complete time to get properly absorbed by the bloodstream. The other time is during the morning timing, particularly preferable for children, when the medication is completely absorbed by the system during the day time.

How long does it take for the allergy medication to work?

Different medications have different timings to work on and provide relief to the patient. Similarly, with allergy medications the time to work on varies.

The anti-histamines start working within one to two hours, whereas Leukotriene antagonists and provide relief to the person within two days. Using Cromolyn Sodium which is again used to treat nasal symptoms, starts working within two days. Steroids are also taken for allergies requires eight hours to become effective.

The above article helps explain the right time to take allergy medication and the other factors which should be considered. Although the right time to eat these medicines is during the night time when the medication is completely absorbed in the blood stream.

 

The Uses and Significance of Buspirone Impurity

Buspirone, also known as Buspar , is used in medicines for the treatment of anxiety related disorders. Though there are various medicines available to treat anxiety, but Buspirone is different because it is free from physical dependency risks and also avoids any withdrawal symptoms. Therefore, it is preferred over other medicines.

Pharmaceutically, Buspirone does not come under the categories of barbiturates or benzodiazepines. May be this is why it is risk free from related symptoms of other medications. The medicines that have Buspirone constituent help people in enhanced and more clear way of thinking without worrying much about any issues. The medicine also helps in curbing excessive sweating and asymmetrical heart beats by acting on the neurotransmitters of the brain.

Dosage Of  Buspirone Impurities

The medicines with Buspirone are usually in the form of oral tablets. These are advised for consumption in 2-3 dosages per day as per the patient’s condition and physician’s advice. Doctor’s advice to consume the medicine either before or after food. You must follow the instructions and dosage advice given by the doctor to see noticeable results.

The most important thing to do while consuming Buspirone medicine is to stick to the restrictions and constraints. One important factor is alcohol. You must strictly avoid consuming alcohol if your doctor has restricted you from it. It is essential to know that consuming alcohol may cause increase in the level of Buspirone in your body. Restricting yourself to the prescribed dosage will help you recover faster.

Prohibitions during medication

When you meet your doctor and discuss your ailment, ensure that you share all your medication history and allergies. Especially when your physician prescribes you Buspirone, it is necessary to give importance to your body allergens. This medication may have constituents that can cause harm to your physiological system. Whereas sticking to the prohibitions will ensure you better treatments in less time.

And, if you have any other complications or diseases and you are taking some other medicines as well, then you must share it with your doctor to avoid all future complications. Let your doctor know about your medical history, specifically when there is any complication like Parkinson’s disease or bipolar disorder.

When your doctor prescribes you Buspirone impurity, try to follow your doctor’s advice. It is recommended that during conditions like pregnancy it can prove to be the best medication to avoid stress and tension.

Effects of the Buspirone

To understand the effects of Buspirone, it is necessary to understand the interaction of this medicine with other medicines. Therefore, to be on the safe side, let your doctor know about all your medicinal information. If you are taking any other drugs, the doctor can study and let you know better outcome.

If you are under medication or treatment for sleep disorders and anaesthetics, then these will have a drowsy effect on you. Therefore, avoid consuming these when under medicines buspirone impurity, because it can be dangerous. For better results, be careful about these additional things.

Olympus: The reliable impurities standard supplier

Olympus Chemicals and Fertilizers is a leading manufacturer and impurities stand supplier in India and across the globe. The quality of chemicals manufactured by the company are unmatched in the market. If you are searching for a reliable source that can deliver you quality products or match your requirements for an impurities standard supplier, then your search is over. Olympus assures you the best in industry products.

Though impurities are considered to be unwanted components in chemicals and drugs and are usually filtered off using various technologies, but these have another side too. Often it happens that these chemicals that are of no use to human beings directly are found to be very beneficial from some other perspectives. Chemical impurities are one of such items. Therefore, industrial manufacturing and isolation of these impurities is carried out at Olympus to meet the demands for these chemicals.

With the goal of becoming a global leader and producer of impurities to across all industries, we manufacture around 40 chemical impurities such as AZITHROMYCIN IMPURITY ; ACYCLOVIR IMPURITY; AMBROXOL IMPURITY; ATENOLOL IMPURITY; GLIPIZIDE IMPURITY; BUSPIRONE IMPURITY; CANDESARTAN; CARVEDILOL IMPURITY; GABAPENTIN IMPURITY; LEVOTHYROXINE IMPURITY; QUETIAPINE IMPURITY; and a lot more.

Goal and activities:

We at Olympus Chemicals and Fertilizers work with the sole goal to become the largest producer and distributer of chemicals and impurities that are useful to various industries. We started our journey with the ambition to wipe out all the issues related to the chemical impurities industry in the market.

We have grown to be one of such organizations that we dreamt long back. We have nurtured our company with great perseverance and hard work. Therefore, we are known amongst the most renowned chemical impurities manufacturer across the nation. We are prepared to meet the demands of any size for chemical impurities.

We take complete care to deliver on our promises and maintain the quality of our products as well. Olympus is known as an impurities standard supplier. Whatever if your impurities requirement, get in touch with us and place your order. You will experience the smoothest transaction ever.

Our specialization

We develop a wide range of chemicals and associated impurities that are in high demand in the country and around the world. We have 40 + varieties of impurities listed in our product catalogue that are used in various drug industries. The impurities are listed under the products and services section. You may check out for the details.

The quality of our products is highly recommended by our loyal customers who have been associated with us from several years. We guarantee the best in class products and services to all our clients. For any query related to chemical impurities, you can get in touch with us.

Research Team:

We have a specialized team of qualified scientists who have years of experience and expertise in manufacturing process of chemicals and chemical impurities. Our scientists are closely involved in the research and development work being carried out at our synthesis facilities. No doubt, everyone is playing earnest role in making Olympus an impurities standard supplier.

Manufactured Levothyroxine can be efficiently used to treat hyperthyroidism & related symptoms

Learn about Levothyroxine impurity and related information. Levothyroxine, or L-thyroxine, is an artificial form of the thyroxine hormone that is used to cure related ailments. The thyroid hormones, triiodothyronine (T3) and thyroxin (T4) are primarily responsible for regulation of metabolism. Tyrosine-based these two hormones are produced by the thyroid gland. Both T3 and T4 are used to treat thyroid hormone deficiency known as hypothyroidism, including the severe form known as myxedema coma. The pharmaceutical name of Levothyroxine sodium (T4) is Levothyroxine more pure, synthetic form of Thyroid.

INDICATIONS:

Introduced in the 1950s Levothyroxine is typically used in the cure for people with hypothyroidism that regularly requires lifelong thyroid hormone remedy. Levothyroxine is also used to treat subclinical hypothyroidism which is defined by araised TSH level and is milder than usual. Such people may be asymptomatic and can’t be predicted whether they should be treated or they don’t require any sort of treatment.

CONTRAINDICATIONS:

Levothyroxine is contraindicated in the following:

• Levothyroxine degrades rapidly with exposure to light, moisture, and oxygen.
• thyroid disorder called thyrotoxicosis
• sort of heart, coronary artery disease, or any history of blood clots
• diabetes (insulin or oral medication dosages must be changed when you start Levothyroxine medicine)
• anemia
• low bone mineral density or osteoporosis
• any problems with your pituitary gland
• food or drug allergy
• untreated adrenal gland disorder
• Not suggested in people who have had a recent heart attack.

During the manufacturing process or storage of the drug elements, impurities present in the form of by-products or so called process impurities are possible.

All impurities of Levothyroxine obtained are given below.

1. Levothyroxine T4-Amine O-methyl Impurity / O-Methyl-Tetraiodothyroethylamine
2. Levothyroxine acetamide Impurities (T4-Acetamide)
3. Levothyroxine EP Impurities A, Levothyroxine
4. Levothyroxine EP Impurities C, T3-Acetic Acid (USP)
5. Levothyroxine EP Impurities D, T4-Acetic Acid (USP)
6. Levothyroxine EP Impurities F, Levothyroxine T6 Impurity (USP)
7. Levothyroxine EP Impurities H, T4-Benzoic Acid (USP)
8. Levothyroxine EP Impurities I, T4-Aldehyde (USP)
9. Levothyroxine EP Impurity J, 3,3’-Diiodo-L-Thyronine
10. Levothyroxine EP Impurity K, 3,3’,5’-Triiodo-L-Thyronine
11. Levothyroxine N-Acetyl Impurities, 1 N-Acetyl-T4 (USP)
12. Levothyroxine N-Formyl Impurity,N-Formyl-T4 (USP)
13. Levothyroxine N-Methylamide (USP)
14. Levothyroxine O-Methyl impurity
15. Levothyroxine T4-Hydroxy Acetic Acid Impurities
16. Levothyroxine T4-Thyrolactic acid Impurities

SIDE EFFECTS:

Excessive dosages include weight loss, disability in tolerating heat, sweating, anxiety, sleeping problems, shivering, and rise in heartbeat rate. Consult your doctor if you had a recent heart attack, or experience any symptoms of a heart attack such as chest pain or heavy feeling in heart, pain spreading to the shoulder, nausea, sweating or general ill feeling). Consuming this during pregnancy has been found to be safe if recommendation of dosing is based on regular check-ups of TSH and T4 levels in the blood. One benefit of treating this people with Levothyroxine therapy is preventing enhancement of hypothyroidism.

Manufactured Levothyroxine can be efficiently used to treat hyperthyroidism and related symptoms. The process of synthesizing artificial Levothyroxine is well documented and the Levothyroxine impurities are stringent. These are based on the guidelines of the ICH & pharmacopeia.

Implications of Solifenacin Impurity in Drugs

The medicinal impurity Solifenacin Impurity is used in medicines prepared to treat bladder problems. The drug Solifenacin is used to cure overactive urinary bladders. Usually people facing problems such as frequent urination, or an immediate urgency to urinate, or leakage of urine, are treated with doses of Solifenacin. It is basically considered as a muscarinic receptor antagonist.

The working of Solifenacin is accomplished by blocking or retarding the action of specific chemical substances in our body. This in turn helps the patients in reduction of urination complications that are caused by overactive bladder. But, it is recommended not to take the drug if the patient is allergic to any of its ingredients.It should be noted that the Solifenacin drug is being effective in reducing the complications of an overactive bladder.

The complication of an overactive bladder is a widespread across the globe. And, this results in having an adverse effect on a person’s identity and the quality of life. The issue of frequent or uncontrolled urination does impact the overall physiological phenomenon in human body. The basic medication for treating an overactive bladder and or the urgency incontinence is given as in small doses of antimuscarinic drug such as Solifenacin and along with a combination of behavioural therapy.

It is informative to know that Solifenacin succinate was introduced in the year 2005. And, it has successfully proved itself in the short and long term clinical trials as well. Solifenacin is known as a M3 receptor antagonist that has a half-life period of about 45 to 68 hours. The effectiveness of the drug solifenacinin curing the diseases related to overactive bladder has been proved in several clinical trials.

How the drug Solifenacin works?

The treatment of overactive bladder by having Solifenacin doses is known to all now.The main thing to understand here is that an overactive bladder and a normal one function distinctly.The phenomenon of a normal bladder to swell like a balloon when it gets filled with urine is quiet natural. This is what we world call a regular event. It then sends signals to the brain that it should be emptied. And, when you go to urinate, the urinary bladder contracts to expel the urine out.

While in case of an overactive bladder, the muscle of the urinary bladder begins contractions before the bladder is filled to its maximum volume. This makes the muscle work over time. This is why a person suffering with the complication faces the sudden urges to urinate.

Here comes the role to be played by the drug Solefenacin. It helps the muscle of the urinary bladder to contract according to the need. It does so by binding the muscle with some receptors or natural body proteins. And, as a result the urge to urinate decreases.

The impurities associated with Solefenacin:

The drug Solifenacin comes associated with impurities such as Solifenacin impurity A, B, and C, RR Solifenacin, Solifenacin SS Methanone Impurity, Solifenacin succinate, RS Solifenacin, SS Solifenacin, Solifenacin RS Methanone Impurity, and Solifenacin Isomer.

Loratadine is in the list of essential medicines of World health organization

Introduction

Loratadine is available in the market under the brand name Claritin among others, and it is a medication used to treat allergies including allergic rhinitis (hay fever) and hives. It is likewise accessible in mix with pseudoephedrine, a decongestant, known as loratadine/pseudoephedrine and is taken orally. Its consumption is related to some side effects such as sleepiness, headache and dry mouth. However it does not include any serious side effects and those are rare which might include allergic reactions, liver problems and seizures. Its use in pregnancy is found to be in safer hands but yet not fully studied. It is highly restricted for children below two years of age. It falls under second generation anti histamine family of medicines.

Discovered in the year 1981, Loratadine came into existence in the market in the year 1993. It has its name in the list of essential medicines of World health organization. It is among the most effective and safe medicines required for health. It is also available as generic medication and is available over the counter.
It is applicable for a variety of health irregularities including hay fever, allergies, rhinitis, urticaria, chronic idiopathic urticaria, and other skin allergies. When nasal and eye symptoms such as sneezing, runny nose, itchiness and burning eyes occur during allergic rhinitis, Loratadine is highly effective. It is also known to work for Kimura’s disease as it attenuated the itching similar to cetrizine with less sedating effects.

Availability
Loratadine is available in variety of forms including tablets, oral suspension and syrup and it is also available in the combination with pseudoephedrine. It is also sold in the market in the form of quick dissolving tablets so that these can get quickly into one’s circulatory system, however, this form requires special handling to prevent degradation in the package.
As of 2017 loratadine is available under many brand names and dosage forms worldwide, including several combination drug formulations which are as follows: with pseudoephedrine, ambroxol, salbutamol, paracetamol, betamethasone, phenylephrine, and dexamethasone.

NMR structures
Based on the NMR spectral data, the impurities are detected by the experts. The molecular configuration of loratadine was scrutinized by huge range, infrared spectrum, 1H-nuclear magnetic resonance spectrum, 13C-NMR scale and 1Hdetected heteronuclear multiplc-quantum consistency spectrum. These impurities are the results of isolation from sample of loratadine using reverse phase preparative High performance liquid chromatography.
No adverse effects
It is a non sedating antihistamine as it penetrates the blood or brain barrier to a smaller extent. Some of the possible side effects include headache and anti muscarinic effects, dry mouth, urinary retention, blurred vision and gastro intestinal problems.
Loratadine medicines should be discontinued if any skin allergy seems to be persistent and show positive results for dermal activity indicators.
Chemical Action
Loratadine is a tricyclic antihistamine, acting as a selective inverse agonist of peripheral histamine H1-receptors.
Given orally, it is very well absorbed from the gastrointestinal tract, and has a quick first-pass hepatic metabolism.
It is almost totally (97–99%) bound to plasma proteins. Its metabolite desloratadine, which is largely responsible for the anti histaminergic effects, binds to plasma proteins by 73–76%.
Its peak effect occurs after one- two hours, and its biological half-life is on average 8 hours with desloratadine's half-life is 27 hours, liable for its continuing outcome.
About 40% of it is excreted as conjugated metabolites into the urine, and a similar amount is excreted into the feces. Many traces of unmetabolised loratadine can be found in the urine.
If we see the chemical structure, it is directly allied to tricyclic antidepressants, for example imipramine, and is abstractedly allied to the a usual antipsychotic quetiapine.
There are many related products with the parent drug Loratadine. Some of them include:
Loratadine EP impurity d (Desloratadine), Loratadine-d5, Desloratadine-d5, 3-hydroxy desloratadine HCl, 4-hydroxymethyl loratadine, 3-hydroxy desloratadine=d4, 3-hydroxy desloratadine pyridine N- oxide, Desloratadine impurity-3, Desloratadine impurity 4, N-formyl desloratadine, Loratadine EP impurity G, Desloratadine N-hydroxypiperidine, desloratadine EP impurity B, desloratadine Impurity A, N-acetyl desloratadine, 12-hydroxy loratadine, 12-fluoro dihydroloratadine, and many more.
The molecular formula of Loratadine EP impurity C is C22H22Cl2N202 and its molecular weight is 417.34 with TLC no L-1026. We confirm your best excellence products by our study and scientific team. We at Olympus Impurities provide you basic substances and custom synthesis from gram to kg scale with great quality & reasonable rates. Our exponential progression is credited to our to a great degree qualified group of specialists having capability in research and growth with several years of industry knowledge.